Alzheimer's disease is a demographic time bomb. Since 1975, the number of Americans afflicted has risen from five hundred thousand to five million; over the next fifty years, an estimated eighty to one hundred million more people worldwide will succumb to it. But it is the story behind these numbers that makes The Forgetting such a landmark work. A magnificent synthesis of history, science, politics, psychology, and profound human drama, the book explores the nature of a disease that attacks not merely memory but the very core of our human identity.

Delving into such diverse areas as art history, literature, genetics, and neurobiology, David Shenk shows that Alzheimer's particular terror, the gradual eradication of memory and of mind is as old as humankind itself. He convincingly posits that such historical figures as Ralph Waldo Emerson, Jonathan Swift and Frederick Law Olmstead were caught in the disease's insidious grip. Moving portraits of contemporary patients, their families, and their caregivers drive home the sad pattern of regression Alzheimer's exacts, a pathology that eerily mirrors child development in reverse. Yet Shenk offers a well of empathy and understanding for families striving to better understand and come to terms with their loss.

With equal mastery Shenk charts the complicated race to find a cure. As scientists pursue a treatment worth billions of dollars, the brutal competition among them poses a serious threat to the traditional ethic of sharing vital research. But there are heartening signs of progress, and for the first time there is excitement among scientists that a cure may indeed be possible.

Shenk eloquently calls Alzheimer's "death by a thousand subtractions." The Forgetting is at once a powerful examination of what this means and a forthright discussion of the impact this epidemic will have on the life of every reader.