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  • The Grandest Challenge
  • Written by Abdallah Daar and Peter Singer
  • Format: Trade Paperback | ISBN: 9780385667197
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Taking Life-Saving Science from Lab to Village

Written by Abdallah DaarAuthor Alerts:  Random House will alert you to new works by Abdallah Daar and Peter A. SingerAuthor Alerts:  Random House will alert you to new works by Peter A. Singer

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On Sale: September 20, 2011
Pages: 352 | ISBN: 978-0-307-36817-1
Published by : Doubleday Canada Doubleday CAN Titles
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Synopsis|Excerpt

Synopsis

The Grandest Challenge begins with a simple premise: that every person's life is of equal value, regardless of where in the world he or she lives. It also begins with an alarming fact: that in this age of spectacular scientific advances, it is still those who live in the developed world--mainly the west--who overwhelmingly benefit from our enormous new power to combat disease and enhance food, while those in the developing world are far more likely to die for lack of basic health care and inexpensive nutrition.

As personalized medicine, designer drugs, and high-quality nutrients become more readily available than ever in the richest parts of the world, distinguished doctors Abdallah Daar and Peter Singer urge us to pause and ask these vital questions: Who will have access to the life-enhancing advances of biotechnology? And who are these advances ultimately meant to help?

In this challenging, controversial, thought-provoking, and humane book, Daar and Singer inspire us to look more deeply at our new science, and at the revolution that is already changing all of our lives.

Excerpt

Our inspiration for writing this book stems from a simple but powerful fact: If your home is in London, New York or Toronto, you can expect to live well into your late seventies or early eighties. If you live in Morogoro, Tanzania, on the other hand, you will live only about half as long.
 
In fact, roughly 90 percent1 of human beings live in poor regions of the world, and their lives are routinely cut short by infectious diseases such as malaria and tuberculosis and hiv/aids, diseases that in rich countries are preventable or controllable. The overwhelming majority of the world’s citizens are also increasingly more susceptible to non-infectious diseases, such as diabetes and heart disease, which in developing nations kill more readily because of poor diet, poor living conditions and limited access to health care.2 For many decades and perhaps even longer, most of us have accepted these inequities as inevitable, a function of the great divide between the lesser-developed world and prosperous nations. But does it really have to be this way? Is there any solid evidence to suggest that life expectancy in some places must necessarily be shorter than in others? And is a life in the developed world really more valuable than the life of someone living in a poorer region?
 
Absolutely not.
 
In fact, with the mapping of the human genome we are poised at the edge of a revolutionary wave of science, one that offers incredible opportunities to improve life sciences and medical possibilities—for all people on Earth. In this book, we will tour the groundbreaking new discoveries and technologies spawned by the Human Genome Project, innovations that will change many aspects of modern medicine, including the way drugs and vaccines are discovered and developed, and how diagnoses are made.
 
We will also pose a critical question: now that we have such extraordinary capabilities, what will we use this power to achieve? To create designer drugs for the rich, which will only widen the health gap between rich and poor? Or will we finally choose to tap the enormous potential of the new science to address the needs of 90 percent of the world?
 
We are two scientists—one born in an affluent Canadian city, the other in a poor Tanzanian one. A number of years ago, we joined forces to pursue an audacious goal: to use modern genomic science to give a child in sub-Saharan Africa—or any other disadvantaged area—the chance to live as long and healthy a life as a child in New York or Toronto. Contrary to what many people believe, this goal is not a grandiose, abstract ambition. Rather, it is a scientific and ethical mission that, even as we write these words, is being put into practice in labs and in villages around the globe.
 
It is true that until recently, the Human Genome Project, an epic scientific achievement that is turning information hidden in the double helix of DNA into a readable language, ignored the needs of the developing world. Most scientists thought that genomic research and applications were too sophisticated to be of use to people in poor countries. But imagine if we challenged that thinking. Imagine what would happen if the ability to read the code of life were applied specifically to problems of the poor. Suddenly, recently discovered cutting-edge powers to heal would be available to the very people who need them most. This kind of thinking could positively change the world we all live in, and save tens of millions of lives.
 
Here’s the good news: it’s now starting to happen. Exciting research is under way all around the world, and in this book we will be your guides through both the thrilling scientific and medical exploits of the past decade and the most promising of today’s innovations in life sciences, those that hold the greatest possibility for improving the health of the world’s poorest and most disenfranchised citizens. We will tell the story of how, in 2003, a half-a-billion-dollar investment from the Bill & Melinda Gates Foundation was deployed to help researchers use the new life-sciences revolution to fight ancient diseases such as malaria from new angles. In California, Australia and London, scientists are now tweaking the DNA of mosquitoes to stop them from spreading malaria. In Seattle, a malaria vaccine is being developed that knocks out genes the malaria parasite needs to survive in the human body.3 Some of the world’s greatest researchers are, at last, focusing on the problem of malaria in the developing world and using the newest scientific breakthroughs to address an age-old scourge. And this scientific awakening is not limited just to malaria but is growing to cover problems as diverse as dengue fever, tuberculosis, pneumonia and diarrhea, all of which are serious ailments in the developing world.
 
But acquiring the knowledge is only one half of the solution, and only one half of the story we tell. How do you transfer the knowledge found in labs around the world right to the hands of the poor in disadvantaged villages? Both of us have devoted much of our professional lives to answering that very question, and what we can tell you is that it’s a long road from lab to village, with many roadblocks to overcome. In this book, we will take you to labs in India and China that have become potent new players in biotechnology and in the discovery and manufacture of drugs. We will go to Bangalore, where one of India’s richest women started a biotechnology company that supplies affordable insulin to India’s growing population of diabetics.
 
We will go to Hyderabad, where a biotechnology company brought down the price of hepatitis B vaccine more than twentyfold through clever thinking and innovation. In these pages, you will also meet scientists, thinkers, doctors, heads of state, CEOs, ethicists and ordinary people who have taken up the call to action to close the gap between the developed and developing worlds.
 
Beyond encountering the people and places on the forefront of a revolution in life sciences, you will also learn about the profound ethical challenges we face on the road ahead. How do you persuade a rural, isolated community to test a new genetically modified mosquito? How do you get female sex workers to try out an anti-HIV gel that could save their lives? How do you obtain consent to trials in a way that respects the health, cultural beliefs and social structures of individual traditional communities around the world? How do you overcome decades of suspicion of multinational companies so that private organizations can contribute to finding a cure to a killer disease? How do you promote the building of labs and other facilities, not in the developed world but close to the people who need them most? How do you encourage companies to make lifesaving drugs and vaccines more affordable? And finally, how do you handle the political roadblocks that can stymie even the most creative and important of scientific endeavours?
 
We contend that if we can answer these questions and overcome these obstacles, we can not only save lives, we can begin to imagine a new world. True innovation means that the discovery of new cures and remedies will take place not only in Stanford and Oxford but in Bangalore, Shanghai and Cape Town. It means the cities of the poor world will begin to reap the health and economic benefits of science. The greatest gift for poor nations is the scientific power to heal themselves.


From the Hardcover edition.
Peter A. Singer|Author Desktop

About Peter A. Singer

Peter A. Singer - The Grandest Challenge
PETER SINGER is Director of the McLaughlin-Rotman Centre for Global Health and Professor of Medicine at the University of Toronto. He has advised the Bill and Melinda Gates Foundation, the UN Secretary-General's Office, the Government of Canada, and Pepsico Inc. He is also a sought-after commentator and public speaker.

Author Q&A

In 1990, one study revealed that only 10 percent of global spending on health research was used to study conditions in developing countries, even though people there suffered 90 percent of the global disease burden. This became known as the 10/90 gap. Citizens in the United States, Canada and Western Europe were getting the lion's share of health research dollars even though their people suffered only a small fraction of the world's diseases. In other words, if you were an impotent, depressed, rich adult man living in the West, science delivered for you, in the form of Viagra and Prozac and a host of other remedies. If you were a poor person in Tanzania, you likely died long before you had to worry about the onset of midlife health concerns.
 
One big problem I started to see was that drug companies in the late 1990s felt the world's poor weren't a viable market because they couldn't ever pay back the cost of discovering, testing and bringing to market new drugs, a burden that the major companies claimed cost them up to a billion dollars for each new drug. In the last quarter of the twentieth century, pharmaceutical companies developed 1,393 new drugs, but only 16 of them were created to combat tropical diseases and TB.
 
Even when scientists discovered a remedy for a disease that affected both rich and poor, it took a long time to get it to the poor. When the hepatitis B vaccine was developed in the late 1960s,34 for instance, it quickly became widely available in the rich world, and today is routinely given to schoolchildren. In the developing world, however, where most of the world's hepatitis resides and where the virus is a common cause of primary liver cancer, the vaccine is still not widely available. In other words, the people who need the vaccine the most are the least likely to get it.
 
I became determined to change this, and in 1998, a year after my sister's death, I left my high-powered post as chief of surgery in Oman to begin an uncharted journey into the world of global public health. My move coincided with the extraordinary acceleration of the genetic revolution that had been building for a century, ever since Gregor Mendel conducted his meticulous pea-growing experiments to show how traits - or genes, as we now know them - are inherited. I knew that genetic science was still largely confined to the most sophisticated labs in the rich world, but I also saw that this revolution could offer hope to developing nations.
 
In 1998, I began working with my colleague Jean-François Mattei on a report for the World Health Organization. Together, we explored the ethical, scientific, social and legal implications of medical genetics and biotechnology, and how these might apply to global health.


From the Hardcover edition.

Praise

Praise

Praise for The Grandest Challenge
"The Grandest Challenge is not only enlightening, solution orientated and deeply personal but it also encourages the reader to challenge the existing norm and encourages us to ask ourselves pivotal questions."
—The Independent (UK)

  • The Grandest Challenge by Dr. Abdallah Daar & Dr. Peter Singer
  • January 15, 2013
  • Social Science
  • Anchor Canada
  • $22.00
  • 9780385667197

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