1. What and where is Sisterland? If you have a sister, do you see any of your own relationship with her reflected in the relationship between Kate and Vi?
2. The novel opens with a description of the 1811 earthquake in New Madrid, although everything that follows is set in the near-present. Why do you think the novel begins in this way? How does the historical context change how we see Kate’s story?
3. Do you believe that people can have psychic powers? Have you ever experienced strong intuitions about events that happened later?
4. Do you understand why Kate tries to escape her powers? Would you prefer, like Kate, to be normal, or to be special, like Vi?
5. Kate transforms herself from Daisy Shramm to Kate Tucker. How do names define and shape us?
6. Near the end of the novel, Kate and Vi make an important discovery about their “senses” that upsets everything they thought they knew. Were you as surprised by this revelation as the twins? How do you think it might change their understanding of their childhood?
7. Do Kate and Jeremy have a good marriage?
8. Were you surprised by Kate’s choices at the end? How will her family’s life in the future be different from what it was in the past? Do you think it’s plausible that she can continue to conceal her secret indefinitely?
9. Twins are intriguing to many people. Do you think the interest they elicit is justified? Have you known twins in your own life? If you are a twin, did Sittenfeld’s portrayal of them strike you as realistic?
10. Have you read any of Curtis Sittenfeld’s other novels? If so, do you think this one is like or unlike her earlier work?